Daniel Lind-Ramos is primarily known for his work in assemblage, a type of sculpture made from found and everyday objects. Lind-Ramos uses items he finds on the street as well as gifts from his community. His materials include fishnets, yucca graters, and DVD players.

After Hurricane Maria impacted his birthplace of Puerto Rico in 2017, Lind-Ramos produced large-scale artworks in response. Using materials such as blue FEMA tarps, he captured both the grief and mourning and the recovery and resilience that followed. In his monumental work Figura de Poder (2016–2020), found objects evoke powerful religious and pop culture figures. These range from Chango, the Yoruba deity of thunder, to famed American boxer Muhammad Ali.

Lind-Ramos also works in video, drawing, painting, and performance. In 2021, he was named a MacArthur Fellow, and he is currently a professor at the University of Puerto Rico.